L-Isoleucine, ethyl ester → N-(12-Methoxy-1-oxododecyl)-L-isoleucine, Ethyl ester

HRID 342726노트

반응식

HRID 342726 반응식
[CH2:1]([O:3][C:4](=[O:11])[C@H:5]([C@H:7]([CH2:9][CH3:10])[CH3:8])[NH2:6])[CH3:2].[C:12]([O:15][CH2:16][CH3:17])(=O)C.[CH3:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>>[CH3:12][O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:7][CH2:5][C:4]([NH:6][C@H:5]([C:4]([O:3][CH2:1][CH3:2])=[O:11])[C@H:7]([CH2:9][CH3:10])[CH3:8])=[O:3]

참가 물질

3

반응물 2

HCID 6602175L-Isoleucine, ethyl esterHCID 21899848Ethylacetate heptane

생성물 1

HCID 9929366N-(12-Methoxy-1-oxododecyl)-L-isoleucine, Ethyl ester

실험 절차

The title compound was prepared by the method of Example 14 using the title product of Example 44 (1.1 g, 4 mmol) instead of benzylamine. Chromatography of the crude residue on silica gel using 50--50 ethyl acetate-heptane as eluant gave the title compound (875 mg) as a white powder, m.p. 36.4°-38.1° C. (DSC). The structure was supported by NMR, infrared spectroscopy, optical rotation ([α]36525 +81.9°, CHCl3), elemental analysis, and mass spectroscopy.

출처 및 근거

ORD 기록
ord-3e41b295663947bb85efc671c8ce63fb
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859052

반응 노트

불러오는 중…