4-allyl-5-hydroxy-N-(4-chlorophenyl)indole → 5-hydroxy-4-propyl-N-(4-chlorophenyl)indole

Participants

Reaction Steps

4-allyl-5-hydroxy-N-(4-chlorophenyl)indole (Step C; 1.0 g, 3.54 mmol) was taken up in 25 mL ethyl acetate and hydrogenated (1 atm) at ambient temperature using 5% palladium on charcoal (40 mg) for 2 hours. The reaction was filtered through celite and concentrated in vacuo to provide the title compound which was used without further purification.

Provenance & Evidence