Ethanol → HCID 69823809, compound

Participants

Reaction Steps

A mixture of Methyl-3-Chloro-4(3-(3-phenyl-7-isobutyl-(2H-benzofuran-6-yloxy)butyloxy)-phenyl acetate (328 mg, 0.58 mmoles), hydroxylamine hydrochloride (202 mg, 2.9 mmoles), anhydrous sodium acetate (238 mg, 2.9 mmoles) and ethanol (4 ml) was heated under reflux in a nitrogen atmosphere with magnetic stirring for 2 hr. The mixture was partitioned between ethyl acetate and water. The aqueous phase was extracted twice with ethyl acetate. The combined ethyl acetate phases were washed with water, 10% NaHCO3 solution, and saturated NaCl solution, and dried (MgSO4). Evaporation in vacuo and purification by chromatography (silica gel, 4:1 hexane-ethyl acetate) gave the title compound as a colorless solid.

Provenance & Evidence