反应详情

To a stirred solution of 5-bromo-1-(4-nitro-benzyl)-1H-indole-2-carboxylic acid ethyl ester (2.3 g, 5.7 mmol) in ethanol/water (2:1, 45 ml) at room temperature was added potassium hydroxide (0.96 g, 17.1 mmol). The solution was warmed to reflux for about 3 hours, cooled, and most of the ethanol was removed under reduced pressure. To the residue was added water, 0.5N sodium hydroxide and methylene chloride, and the two-phase mixture was suction filtered to remove some insoluble material. The aqueous layer was acidified to pH 2 with 6N hydrochloric acid, and the precipitate was filtered off, washed with water, and air dried to afford the title compound, (1.66 g).

1. temperatureThe solution was warmed
2. temperatureto reflux for about 3 hours
3. temperaturecooled
4. custommost of the ethanol was removed under reduced pressure
5. additionTo the residue was added water, 0.5N sodium hydroxide and methylene chloride
6. filtrationfiltered
7. customto remove some insoluble material
8. filtrationthe precipitate was filtered off
9. washwashed with water, and air
10. customdried