Formic Acid → HCID 22874822, compound

Participants

Reaction Steps

Bzl-NH2 288 μl (2.64 mmol) and benzyl phenethylketone 592 mg (2.64 mmol) were dissolved in MeOH (5 ml) at rt and the solution was stirred overnight. To the mixture were added formic acid 99.6 μl (2.64 mmol) and cyclohexylisocyanide 298 μl (2.4 mmol) at rt, which was allowed to react at rt for 2 weeks. Insoluble material in MeOH was collected by filtration and washed with MeOH, ether and then n-hexane. The crude product was recrystallized from CHCl3 with the 2 to 1 mixture of ether and n-hexane. Yield 540 mg (48.2%), NMR in CDCl3 ; δ=0.8-1.8 cyclohexyl (11H), δ=2.1-4.75 CH2 (8H), δ=5.45-5.55 NH (1H), δ=7.0-7.4 phenyl (15H), δ=8.25 (main) and 8.4 (minor) formyl (1H).

Provenance & Evidence