Dichloromethane → methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate

참여 물질

역할	이름	HCID	투입량
반응물	Dichloromethane	HCID 6344	—
반응물	Potassium Bromide	HCID 253877	—
반응물	Methyl 2-amino-3-(4-nitrophenyl)propanoate	HCID 560520	—
용매	Dichloromethane methanol	HCID 21226129	—
생성물	methyl 2-[N-(methoxycarbonylmethyl)amino]-3-(4-nitrophenyl)propionate	HCID 11055537	36%

반응 단계

This compound (7) was synthesized from compound 5 using a method analogous to the synthesis described in Example 4. FC (silica gel, first CH2Cl2, then 5% MeOH/CH2Cl2). Yield: 36%. IR (KBr): 3342 (N--H), 1740 (C=O), 1519,1347 (NO2), 1203 (C--O). 1N-NMR (CDCl3): 3.04 (dd, J=7.3, 13.7, 1H); 3.13 (dd, J=6.3, 13.7, 1H); 3.36 (d, J=17.3, 1H); 3.42 (d, J=17.3, 1H); 3.63 (dd, J=6.3, 7.3, 1H); 3.69 (s, 3H); 3.70 (s, 3H); 7.39 (d, J=8.8, 2H); 8.16 (d, J=8.8, 2H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05859215
출처 데이터셋	uspto-grants-1999_01
ORD ID	ord-5aadcbb7ebc04f6a94f09d99c6cc5d9c
출처 메모	uspto-grants-1999_01