Hydrogen Bromide → methyl N-(2-oxo-tetrahydrofur-3-yl)aminoacetate

Participants

Reaction Steps

This compound (9) was synthesized from (±)-α-amino-γ-butyrolactone×HBr using a method analogous to the synthesis described in Example 4. FC (silica gel, CHCl3). Yield: 31%. IR (KBr): 3333 (N--H), 1770, 1740 (C=O), 1216, 1165 (C--O). 1H-NMR (CDCl3): 2.05-2.18 (m, 1H); 2.47-2.57 (m, 1H); 3.57 (d, J=17.6, 1H); 3.63 (d, J=17.6, 1H); 3.64 (dd, J=8.1, 9.8, 1H); 3.75 (s, 3H); 4.21 (dt, J=6.3, 9.8, 1H); 4.42 (dt, J=2.3, 8.8, 1H).

Provenance & Evidence