反应详情

To a suspension of LiAlH4 (910 mg, 23.95 mM) in dry THF (40 ml) under N2 was added the compound from Example 8 (2.22 g, 7.96 mM) in one portion and the resulting mixture refluxed for one hour. The mixture was then cooled in an ice bath and treated successively with distilled water (0.9 ml), 15% NaOH solution (0.9 ml) and water (2.7 ml) in a dropwise manner. The resulting white suspension was filtered through Celite, the filtrate washed thoroughly with THF, and the combined washings concentrated in vacuo. The residue was recrystallized from hexane to give the titled compound (1.89 g, 90% yield) as white crystals, mp 132°-134° C. NMR (CDCl3) δ 0.90 ppm (t, 3H, NCH2CH3), 2.43 (q, 2H, J=7 Hz, NCH2CH3), 2.63 (AB doublet, 1H, J=11 Hz, ##STR19## 2.72 (m, 2H, ##STR20## 3.25 (AB doublet, 1H, J=11 Hz, ##STR21## 5.20 (broad t, 1H, ##STR22## 6.70-7.70 (m, 9H, aromatic H). MS: 265 (M+).

1. temperaturethe resulting mixture refluxed for one hour
2. temperatureThe mixture was then cooled in an ice bath
3. filtrationThe resulting white suspension was filtered through Celite
4. washthe filtrate washed thoroughly with THF
5. concentrationthe combined washings concentrated in vacuo
6. customThe residue was recrystallized from hexane