反应详情

温度

27 °C

Thionyl chloride (1.25 moles) was added to a solution of 2-aminobutyric acid (1 mole) in SD12A3 (95% ethanol/5% toluene) at a temperature of <5° C. When addition was complete, the mixture was stirred at 27° C. for 16 hours and the resulting precipitate filtered off and washed with methyl t-butyl ether to give the desired product as a white solid (97% yield).

1. additionWhen addition
2. filtrationthe resulting precipitate filtered off
3. washwashed with methyl t-butyl ether