Acetic Anhydride → 2-Ethoxymethylene-1-(2-nitro-4-trifluoromethylphenyl)butan-1,3-dione

Participants

Reaction Steps

A mixture of 1-(2-nitro-4-trifluoromethylphenyl)-butan-1,3-dione (-11.0 g), triethyl orthoformate (11.3 g) and acetic anhydride (12.3 g) was stirred and heated at reflux for 3 hours. After cooling, the mixture was evaporated to dryness. Toluene (50 ml) was added and the mixture was evaporated to dryness to give 2-ethoxymethylene-1-(2-nitro-4-trifluoromethylphenyl)-butan-1,3-dione as a crude brown oil which was not further purified.

Provenance & Evidence