反应详情

温度

80 °C

A mixture of 5-cyclopropylcarbonyl-2,2-dimethyl-1,3-dioxan-4,6-dione (23.9 g) and t-butanol (25 g) in dry toluene (80 ml) was stirred and heated at 80° C. for 4 hours. The cooled mixture was washed with water (3×30 ml), dried (anhydrous sodium sulphate), treated with decolourizing charcoal and filtered. The filtrate was evaporated to dryness and the residue was distilled to give t-butyl 3-cyclopropyl-3-oxopropionate (20.2 g) as a clear oil bp 80°-84° C./8 mmHg.

1. washThe cooled mixture was washed with water (3×30 ml)
2. dry with materialdried (anhydrous sodium sulphate)
3. additiontreated with decolourizing charcoal
4. filtrationfiltered
5. customThe filtrate was evaporated to dryness
6. distillationthe residue was distilled