Acetic Anhydride → HCID 19608692, compound

HRID 343062Notes

Reaction equation

HRID 343062 reaction equation
[C:1]1([C:7](=[N:17][OH:18])[CH2:8][C:9]2[CH:14]=[CH:13][C:12]([S:15][CH3:16])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19](OC(=O)C)(=O)[CH3:20]>>[CH3:19][C:20]1[O:18][N:17]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([S:15][CH3:16])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 73630005HCID 73630005, compound

Product 1

HCID 19608692HCID 19608692, compoundYield 48%

Procedure

5-Methyl-4-[4-(methylthio)phenyl]-3-phenylisoxazole was prepared in 48% yield from the reaction of 1-phenyl-2-[4-(methylthio)phenyl]-ethan-1-one oxime (Step 2) and acetic anhydride according to the procedure outlined in Example 4, Step 1: Mass Spectrum: MH+=282. High resolution mass spectrum Calc'd. for C17H15NOS: 281.0874. Found: 281.0875. Anal. Calc'd.: C, 72.57; H, 5.37; N. 4.98; S, 11.39. Found: C, 72.56; H, 5.41; N, 5.00; S, 11.34.

Sources & evidence

ORD record
ord-7e6423631ee548c4aff47ebda87f6bae
Source dataset
uspto-grants-1999_01
Patent number
US05859257

Reaction notes

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