Tetrahydrofuran → HCID 53949575, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-methyl-4-(4-methylthiophenyl)-5-phenylisoxazole (Step 3) (285 mg, 1 mmol) in tetrahydrofuran and methanol (1:1) was added a solution of Oxone® (900 mg, 1.5 mmol) in water (5 ml). The reaction mixture was stirred rapidly at 25° C. for 3 hours. The reaction mixture was extracted with ethyl acetate and the organic extracts dried. After filtration and solvent removal, the crude residue was recrystallized from ethyl acetate and hexane to give pure product as a crystalline solid (250 mg, 79%): mp 144°-145° C. Anal. Calc'd. for C17H15NO3S (313.38): C, 65.16; H, 4.82; N, 4.47; S, 10.23. Found: C, 65.26; H, 4.78; N, 3.99; S, 10.22.

Provenance & Evidence