反应详情

To a solution of 3.04 g (19.2 mmol) of 2-allyl-2-methyl malonic acid, prepared as in Part A, in 50 mL of DCM at 0° C. is added 7 mL of DMF, followed by 6.7 mL (76.8 mmol) of oxalyl chloride. The resulting solution is stirred 1 h at RT, then the solvent and excess oxalyl chloride is removed in vacuo. The residue is dissolved in 100 mL of THF and added dropwise to a stirring solution of 5.0 g (16.0 mmol) of N-Isopropyl-N-(4-methoxy-phenyl)-2-phenylamino acetamide, prepared as in Intermediate 44, in 300 mL of THF maintained at 0° C. The resulting mixture is stirred at RT for 30 min then refluxed for 16 h. The solvents were removed in vacuo and the residue poured into 200 mL of 1H HCl and extracted with EtOAc (2×100 mL). The organics were washed with NaHCO3 (1×100 mL), brine (1×100 mL), dried over MgSO4, and the solvent removed in vacuo. Purification of the brown oil by silica gel flash column chromatography using hexane/EtOAc 1/1 as eluent afforded 4.0 g of 2-(3-Allyl-3-methyl-2,4-dioxo-2,3,4,5-tetrahydro benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-(4-methoxyphenyl) acetamide: 1H NMR (CDCl3, 300 MHz) δ9.53 (s, 1H), 7.27-6.85 (m, 8H), 5.67-5.60 (m, 1H), 5.05-4.93 (m, 2H), 4.73 (d, 1H, J=17), 4.50-4,45 (d, 1H, J=16), 3.77 (s, 3H), 3.60 (d, 1H, J=17), 2.1 (s, 1H), 1.46 (s, 2H), 1.09-1.03 (m, 6H).

1. customthe solvent and excess oxalyl chloride is removed in vacuo
2. dissolutionThe residue is dissolved in 100 mL of THF
3. temperaturemaintained at 0° C
4. stirringThe resulting mixture is stirred at RT for 30 min
5. temperaturethen refluxed for 16 h
6. customThe solvents were removed in vacuo
7. additionthe residue poured into 200 mL of 1H HCl
8. extractionextracted with EtOAc (2×100 mL)
9. washThe organics were washed with NaHCO3 (1×100 mL), brine (1×100 mL)
10. dry with materialdried over MgSO4
11. customthe solvent removed in vacuo
12. customPurification of the brown oil by silica gel flash column chromatography