HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 13744932, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Ethyl 2-chloro-7-(4-methoxyphenylmethylthio)quinolin-3-carboxylate | HCID 13744931 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13744932 | HCID 13744932 | — |
Reaction Steps
The ester from Step 3 (7.76 g) was added to a solution of sodium (920 mg) in anhydrous methanol (50 ml) and the resulting suspension was refluxed under an argon atmosphere for 75 minutes. The mixture was cooled, diluted with CH2Cl2 (200 ml), washed with water (3×50 ml) and reduced to dryness to provide the title compound, m.p. 133°-134.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04761425 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-9b4fcb92c3a540a2a1e2a1fe20f8ad8a |
| Source note | uspto-grants-1988_08 |