Methyl chloroformate → 2-Fluoro-4-methoxycarbonyloxybenzoic acid

HRID 343260Notes

Reaction equation

[CH3:1][O:2][C:3]([O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)=[O:4].[F:15]C1C=C(O)C=CC=1C(O)=O.COC(Cl)=O>>[F:15][C:13]1[CH:14]=[C:6]([O:5][C:3]([O:2][CH3:1])=[O:4])[CH:7]=[CH:8][C:9]=1[C:10]([OH:12])=[O:11]

Participants

Reactant 3

HCID 6586Methyl chloroformate

HCID 27833982-Fluoro-4-hydroxybenzoic Acid

HCID 222422684-[(Methoxycarbonyl)oxy]benzoic acid

Product 1

HCID 542967682-Fluoro-4-methoxycarbonyloxybenzoic acid

Procedure

This was prepared using a similar method to that described for compound 15. Quantities: 2-fluoro-4-hydroxybenzoic acid (26) (0.97 g, 6.23 mmol), methylchloroformate (1.09 g, 11.48 mmol).

Workup

customThis was prepared

Sources & evidence

ORD record: ord-6ebb58d68c9b47519f37846f8b70b865
Source dataset: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05861109

Reaction notes

Loading…