HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluoro-1-iodobenzene → 3-Fluoro-4-octoxy-4'-bromo-2'-fluorobiphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluoro-1-iodobenzene | HCID 2724516 | — |
| Reactant | Boronic acid, [3-fluoro-4-(octyloxy)phenyl]- | HCID 10611926 | — |
| Reactant | HCID 10620805 | HCID 10620805 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 3-Fluoro-4-octoxy-4'-bromo-2'-fluorobiphenyl | HCID 10524852 | — |
Reaction Steps
This was prepared using a similar method to that described for compound 8. The product is a low melting solid and was used without further purification. Quantities: 3-fluoro-4-octyloxyphenylboronic acid (6) (6.83 g, 0.026 mol), 1-bromo-3-fluoro-4-iodobenzene (6.92 g, 0.023 mol), tetrakis(triphenylphosphine)palladium(0) (1 g, 0.87 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05861109 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-9ad3fdb5405f4672a67a8ac18f0dff6e |
| Source note | uspto-grants-1999_01 |