Boron tribromide → HCID 136023965, compound

HRID 343288Notes

Reaction equation

HRID 343288 reaction equation
[Cl:1][C:2]1[C:3]([C:11]2[CH:16]=[CH:15][C:14]([O:17]C(C)(C)C)=[CH:13][C:12]=2[F:22])=[N:4][O:5][C:6]=1[C:7]([F:10])([F:9])[F:8].B(Br)(Br)Br>C(Cl)Cl>[F:22][C:12]1[CH:13]=[C:14]([OH:17])[CH:15]=[CH:16][C:11]=1[C:3]1[C:2]([Cl:1])=[C:6]([C:7]([F:8])([F:9])[F:10])[O:5][N:4]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 54381819HCID 54381819, compound

Product 1

HCID 136023965HCID 136023965, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound is prepared in a manner analogous to that of Step H of Example 1, using 3.2 grams (0.010 mole) of 4-chloro-3-[2-fluoro-4-(1,1-dimethylethoxy)phenyl]-5-trifluoromethylisoxazole and 20 mL (0.020 mole) of 1M boron tribromide (in methylene chloride) in 50 mL of methylene chloride, yielding 3-fluoro-4-(4-chloro-5-trifluoromethyl-isoxazol-3-yl)phenol.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step H of Example 1

Sources & evidence

ORD record
ord-6c9faded6b2b486e858ce0108c8b6850
Source dataset
uspto-grants-1999_01
Patent number
US05861359

Reaction notes

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