反应详情

A solution of 2-amino-6-chloropyrazine (5.0 g) and N-bromosuccinimide (13.9 g) in chloroform (200 ml) was heated under reflux for 2 hours. Insoluble material was removed by filtration and the filtrate was concentrated by evaporation. The residue was purified by flash chromatography on silica gel, eluting with dichloromethane, to give 2-amino-5-bromo-6-chloropyrazine (1.5 g); m.p. 120°-122° C.; mass spectrum (+ve CI): 208 (M+H)+.

1. temperatureunder reflux for 2 hours
2. customInsoluble material was removed by filtration
3. concentrationthe filtrate was concentrated by evaporation
4. customThe residue was purified by flash chromatography on silica gel
5. washeluting with dichloromethane