Methanol → HCID 4248726, compound

Participants

Reaction Steps

2,4-Dichloro-5-nitropyrimidine (9.7 g), prepared using the procedure in J. Chem. Soc., 1951, 1565, was added to a solution of sodium methoxide in methanol (obtained from sodium (2.8 g) and methanol (50 ml)) at 0°-5° C. The mixture was heated at reflux for 2 hours and poured onto ice water (200 ml). The suspended solid was collected by filtration and dried under vacuum to give 2,4-dimethoxy-5-nitropyrimidine (7.6 g) as a solid, m.p. 92°-93° C.

Provenance & Evidence