反应详情

Sodium methanethiolate (0.342 g) was added to a solution of 5-amino-2,4-dichloropyrimidine (1 g) in methanol (5 ml) and the mixture was heated at reflux for 2 hours. Volatile material was then removed by evaporation and water (1 ml) was added. The suspended solid was collected by filtration, washed with hexane (10 ml) and dried under vacuum to give 5-amino-2-chloro-4-methylthiopyrimidine (0.3 g); 1H NMR (CDCl3): 2.55 (s, 3H), 7.75 (s, 1H); mass spectrum (+ve CI): 175 (M+H)+.

1. temperaturethe mixture was heated
2. temperatureat reflux for 2 hours
3. customVolatile material was then removed by evaporation and water (1 ml)
4. additionwas added
5. filtrationThe suspended solid was collected by filtration
6. washwashed with hexane (10 ml)
7. customdried under vacuum