Water → HCID 178517755, compound

HRID 343421Notes

Reaction equation

HRID 343421 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.[Br:9]Br.O>C(O)(=O)C>[Br:9][C:4]1[C:5]([OH:8])=[N:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 1785160645-chloropyridin-2-ol

Product 1

HCID 178517755HCID 178517755, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 5-chloro-2-hydroxypyridine (100 g) and bromine (40.1 mL) in acetic acid (400 mL) was stirred at r.t. for 1 h. The mixture was poured into 3 L of water and stirred for 30 min then filtered. The residual solid was washed with 2 L of cold water, air dried and then coevaporated with toluene three times and with benzene two times. The white solid (81 g) so obtained was used in the subsequent reaction.

Workup

  1. stirringstirred for 30 min
  2. filtrationthen filtered
  3. washThe residual solid was washed with 2 L of cold water, air
  4. customdried

Sources & evidence

ORD record
ord-5a2c73eb5a8b4324a7cb2134dd9e7de5
Source dataset
uspto-grants-1999_01
Patent number
US05861419

Reaction notes

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