反应详情

To a 100-mL round-bottomed flask was added 1,1-cyclohexanediacetic acid (2.03 g, 9.99 mmol) and acetic anhydride (11.6 mL). The reaction mixture was held at reflux for 2 hours, and then cooled to room temperature. Volatiles were removed via vacuum distillation (0.1 Torr, 20°-60° C.). The resulting crude product was dried under vacuum (0.1 Torr) at 80° C. for 14 hours to yield the title compound as a white solid which was used without further purification (1.75 g, 96%).

1. temperatureat reflux for 2 hours
2. customVolatiles were removed via vacuum distillation (0.1 Torr, 20°-60° C.)
3. dry with materialThe resulting crude product was dried under vacuum (0.1 Torr) at 80° C. for 14 hours