反应详情

Alternately, combine 4-phenyl-4-cyano-piperidine hydrochloric acid salt (10 g, 44.9 mmol), benzyl bromide (5.4 mL, 45.4 mmol), and potassium carbonate (25.2g, 182.3 mmol) in tetrahydrofuran/water (80 mL/20 mL). After 18 hours, partition the reaction mixture between water and dichloromethane. Separate The organic layer and extract with water, dry over MgSO4, filter and evaporate invacuo to give a residue. Recrystallize the residue from hexane to give 1-benzyl-4-phenyl-4-cyanopiperidine as a solid: mp; 73°-74° C.

1. custompartition the reaction mixture between water and dichloromethane
2. customSeparate The organic layer
3. extractionextract with water
4. dry with materialdry over MgSO4
5. filtrationfilter
6. customevaporate invacuo
7. customto give a residue
8. customRecrystallize the residue from hexane