Ammonia → (3-(3,4-Dimethylphenyl)-5-oxopyrrolidin-3-yl)acetic acid ethyl ester

HRID 343535Notes

Reaction equation

HRID 343535 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]([C:21]#[N:22])([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=1)[CH2:7][C:8](OCC)=[O:9])[CH3:2].C(O)C.N>[Ni].CO.ClCCl>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=2)[CH2:7][C:8](=[O:9])[NH:22][CH2:21]1)[CH3:2]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 702EthanolHCID 538454283-Cyano-3-(3,4-dimethylphenyl)pentanedioic acid diethyl ester

Product 1

HCID 54260207(3-(3,4-Dimethylphenyl)-5-oxopyrrolidin-3-yl)acetic acid ethyl ester

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 21226129Dichloromethane methanolSolvent

Procedure

Combine 3-cyano-3-(3,4-dimethylphenyl)pentanedioic acid diethyl ester (56 g, 177 mmol) and ethanol (500 mL) in a Parr bottle. Add Raney nickel (50 g) and an aqueous concentrated ammonia solution (85 mL). Hydrogenate at 50° C. and 100 psi for 48 h. Filter through a celite pad and rinse the solids with ethanol. Evaporate the filtrate in vacuo to obtain a residue. Chromatograph the residue on silica gel eluting with 6% methanol/dichloromethane to give the title compound.

Workup

  1. filtrationFilter through a celite pad
  2. washrinse the solids with ethanol
  3. customEvaporate the filtrate in vacuo
  4. customto obtain a residue

Sources & evidence

ORD record
ord-8211223097874d88aaa49beb36d683bd
Source dataset
uspto-grants-1999_01
Patent number
US05861417

Reaction notes

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