Methanol → 5-Amino-2,3-dimethylbenzoic acid

Participants

Reaction Steps

Combine methyl 2-methyl-5-nitrobenzoate (5.32 g, 27.2 mmol) and methanol (100 mL). Add 5% palladium-on-carbon (0.27 g). Hydrogenate on a pressure apparatus at 50 psi. After 18 hours, filter through celite to remove the catalyst and evaporate the filtrate in vacuo to give methyl 2-methyl-5-aminobenzoic acid: Rf =0.34 (silica gel, ethyl acetate/hexane 1/4).

Provenance & Evidence