Triethylamine → 1-Ethyl-3-(2-ethyl-6-isopropylphenyl)-2-thioxo-imidazolin-4-one

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Reaction Steps

A mixture of the crude N-ethyl glycine (18.4 g), 2-ethyl-6-isopropylphenyl-isothiocyanate, (20.5 g), triethyl amine (20.2 g) and chloroform (300 mL) was heated at reflux for 6 hours. The solvent was evaporated. The residue was dissolved in ethyl acetate (500 mL) and washed with water (500 mL). The organic phase was evaporated to dryness. The residue was dissolved in ethanol (50 mL), then diluted with diethyl ether (200 mL). The solution was saturated with hydrogen chloride. The mixture was filtered. The solid was discarded. The filtrate was evaporated to dryness. Purification was achieved by flash chromatography on silica gel (5-10% ethyl acetate in hexane). Crystallization from diethyl ether/hexane afforded pure title compound (7.5 g) as a white solid, m.p. 77°-79° C. Anal. Calcd. for. C16H22N2OS: C, 66.17; H, 7.64; N, 9.65. Found: C, 66.12; H, 7.77; N, 9.69. Mass spectrum (EI, M.+) m/z 290.

Provenance & Evidence