Triethylamine → 1-Ethyl-3-(2-ethylphenyl)-2-thioxo-imidazolidin-4-one

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Reaction Steps

The title compound was prepared by the procedure described in Example 9 using 16.3 g of 2-ethylphenyl-isothiocyanate, 18.4 g of N-ethyl glycine, 20.2 g of triethyl amine, and 200 mL of chloroform. Purification was achieved by flash chromatography on silica gel (5-10% ethyl acetate in hexane). Crystallization from diethyl ether afforded the title compound (9.12 g) as a white solid, m.p. 71°-73° C. Anal. Calcd. for. C13H16N2OS: C, 62.87; H, 6.49; N, 11.28. Found: C, 62.81; H, 6.43; N, 11.17. Mass spectrum (EI, M.+) m/z 248.

Provenance & Evidence