Sodium Bicarbonate → HCID 54172520, compound

Participants

Reaction Conditions

Reaction Steps

4.2 g of N-(-N-methyl-2(R)-tert-butoxycarbonylamino-3-(triphenylmethylthio)propionyl)-N,O-dimethylhydroxylamine in 15 cm3 of diethyl ether are added, at a temperature in the region of -45° C., to a suspension of 0.386 g of lithium aluminium hydride in 35 cm3 of diethyl ether. The temperature is allowed, with stirring, to rise to approximately 0° C. After cooling to a temperature in the region of -35° C., a solution of 1.77 g of sodium hydrogen carbonate in 6.5 cm3 of water is added. The organic phase is washed 3 times with 10 cm3 of a normal hydrochloric acid solution, then twice with 10 cm3 of a saturated sodium hydrogen carbonate solution and finally with 10 cm3 of a saturated sodium chloride solution. The organic phase is dried over magnesium sulphate, filtered and concentrated under reduced pressure. 2.2 g of N-methyl-N-tert-butoxycarbonyl-S-(triphenylmethyl)cysteinal are obtained, which are used in the following stage without other purification.

Provenance & Evidence