HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyridin-3-yl)-piperidine-4-carboxylic acid amide hydrochloride → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-(pyridin-3-yl)-piperidine-4-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyridin-3-yl)-piperidine-4-carboxylic acid amide hydrochloride | HCID 67559483 | — |
| Reactant | 2-[1-(3,4,5-Trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate | HCID 86750906 | — |
| Product | 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-(pyridin-3-yl)-piperidine-4-carboxylic acid amide | HCID 44319307 | — |
Reaction Steps
Prepare by the method of example 3.3 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (5 mmol) and 4-(pyridin-3-yl)-piperidine-4-carboxylic acid amide hydrochloride (7.5 mmol, 1.5 eq.). Chromatograph on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05861416 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-c390b0ddeb6a480d9bbd712c8ca7a85a |
| Source note | uspto-grants-1999_01 |