Oxalyl chloride → 2-(3,4,5-trimethoxyphenyl)acetyl Chloride

Participants

Role	Name	HCID	Charge
Reactant	Oxalyl chloride	HCID 65578	—
Reactant	3,4,5-Trimethoxyphenylacetic acid	HCID 70372	—
Catalyst	Dimethylformamide	HCID 6228	—
Solvent	Dichloromethane	HCID 6344	—
Product	2-(3,4,5-trimethoxyphenyl)acetyl Chloride	HCID 11032124	—

Reaction Conditions

Temperature	-5 °C

Reaction Steps

Combine 3,4,5-trimethoxy-phenyl-acetic acid (2.26 g, 10 mmol) and dichloromethane (50 mL). Cool to -5° C. using a ice-salt bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (1.74 mL, 20 mmol). after 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05861416
Source dataset	uspto-grants-1999_01
ORD ID	ord-6016ca57d90b42e6bab08cf26c2c315b
Source note	uspto-grants-1999_01