4-Phenylpiperidine-4-carboxamide monohydrochloride → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trifluoro-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide

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Reaction Steps

Prepare by the method of example 27.3.1 using 2-[3-(3,4-dichloro-phenyl)-1(3,4,5-trifluoro-benzoyl)-pyrrolidin -3-yl]-ethyl-methanesulfonate (1 mmol) and 4-phenyl-piperidine -4-carboxylic acid amide hydrochloride (0.29 g, 1.2 mmol). Chromatograph on silica gel eluting sequentially with 50% ethyl acetate/hexane and then 6% methanol/dichloromethane to give the title compound: Rf =0.45 (silica gel, 10% methanol in dichloromethane). Exact mass (FAB+): calculated for C37H46Cl2N3O5 calculated 682.2815. Found 682.2799.

Provenance & Evidence