p-Toluenesulfonic acid → HCID 54554954, compound

Participants

Reaction Steps

A mixture of crude 2-tert-butoxycarbonyl-1-cyclopropyl-3-(2-methyl-3-ethoxy-4-methylsulfonylphenyl)-1,3-propanedione (10 g) and 4-toluenesulfonic acid (2 g) in dry toluene (150 mL) was stirred and heated at reflux for 2 hours. The cooled mixture was washed with a saturated sodium bicarbonate solution (50 mL), dried over magnesium sulfate, and concentrated in vacuo to afford 7 g of the crude product as a yellow oil.

Provenance & Evidence