Hydrochloric Acid → HCID 54166571, compound

Participants

Reaction Steps

A mixture of N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(methoxycarbonylmethyl)-methanesulphonamide (Example 71, WO 96/09295, 1.0 g, 2.357 mmol), 1M sodium hydroxide (12 ml) and 1,4-dioxan (25 ml) was stirred at room temperature for 15 minutes. The resulting solution was acidified to ca. pH5 with 2M hydrochloric acid and concentrated under reduced pressure. The residue was suspended in water (10 ml), collected by filtration and dried under reduced pressure at 80° C. to give N-(carboxymethyl)-N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (876 mg, 91 %) as a white solid, mp 203°-206° C.

Provenance & Evidence