Hydrochloric Acid → HCID 70076116, compound

Participants

Reaction Steps

A stirred mixture of 4-cyano-2-fluorobenzaldehyde (1.94 g, 13 mmol), potassium cyanide (1.69 g, 26 mmol) and ammonium carbonate (4.99 g, 52 mmol) in ethanol-water ((1:1, 20 ml) was heated to 80° C. for 12 hours in a PTFE lined stainless steel sealed reaction vessel. The cooled mixture was diluted with water and cautiously acidified with concentrated hydrochloric acid (15 ml). Extraction with chloroform (2×30 ml) gave 5-(4-cyano-2-fluorophenyl)hydantoin as a yellow glass.

Provenance & Evidence