Hydrochloric Acid → HCID 54369742, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-(2-benzylthio-4-carboxyphenyl)hydantoin (0.375 g, 0.12 mmol) in 2N sodium hydroxide (6 ml, 12 mmol) was heated with stirring in a sealed reaction vessel for 20 hours at 120° C. The cooled solution was acidified wih 2N hydrochloric acid (1 ml) to pH~4 and chromatographed on ion exchange (Dowex 50×8-100). The column was eluted sequentially with water, tetrahydrofuran-water (1:1), water, then 10% pyridine in water. Fractions collected after pyridine water were combined, evaporated to dryness, redissolved in water, then freeze-dried to give the title product as an off-white solid, m.p. ~226° C.

Provenance & Evidence