Hydrochloric Acid → HCID 54087991, compound

Participants

Reaction Steps

A solution of 5-(2-methyl-3,5-dihydroxyphenyl)-hydantoin (400 mg, 1.8 mmol) in 2M sodium hydroxide (4.5 ml, 9 mmol) was heated in a sealed vessel at 110° C. for 48 hours. The reaction mixture was allowed to cool, neutralised with 2M hydrochloric acid and purified by cation-exchange chromatography (Dowex 50×8-100; column eluted sequentially with water,water:THF 1:1 and water again. The amino acid was finally eluted with water:pyridine 9:1). The pyridine was removed in vacuo and the residual solid redissolved in water and freeze-dried to give the title compound as a light brown solid, m.p. 215° C. (dec).

Provenance & Evidence