Hydrochloric Acid → HCID 70079778, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2-butyl-4-cyanobenzaldehyde (0.9 g, 4.8 mmol), potassium cyanide (0.63 g, 9.6 mmol) and ammonium carbonate (1.85 g, 19.2 mmol) in ethanol/water (1:1, 10 ml) was heated with stirring in a sealed vessel at 85° C. overnight. The resulting crude solution was cooled and acidified with 2N hydrochloric acid (10 ml), then extracted with ethyl acetate (3×20 ml), combined, dried, then evaporated to yield a brown oil. Flash chromatography eluting with ethyl acetate/hexane (4:1) gave a pale brown oil lining the flask. It was triturated with ether (20 ml) and filtered off to give 5-(2-butyl-4-cyanophenyl)hydantoin as a white solid.

Provenance & Evidence