反应详情

A solution of 2.09 g (10 mmol) of the compound from Example VIII, 3.14 g (10 mmol) of 2-fluoro-4-iodobenzyl bromide and 2.11 g (11 mmol) of caesium carbonate in 40 ml of DME is stirred at 20° C. under argon for 16 hours. The solvent is then removed in vacuo, the residue is taken up in methylene chloride/water, the aqueous phase is extracted once with methylene chloride and the combined organic phases are dried over sodium sulphate and concentrated. The residue is purified on silica gel using petroleum ether/ethyl acetate (5:1 and 3:1).

1. customThe solvent is then removed in vacuo
2. extractionthe aqueous phase is extracted once with methylene chloride
3. dry with materialthe combined organic phases are dried over sodium sulphate
4. concentrationconcentrated
5. customThe residue is purified on silica gel