HCID 70094582, compound → HCID 22612435, compound

HRID 343971Notes

Reaction equation

HRID 343971 reaction equation
C([O:8][C:9](=[O:32])[C:10]([CH2:26][C:27](=[O:31])[N:28]([CH3:30])[CH3:29])([NH:14][S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:17])=[O:16])[CH:11]([CH3:13])[CH3:12])C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:30][N:28]([CH3:29])[C:27]([CH2:26][C:10]([NH:14][S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:17])=[O:16])([CH:11]([CH3:13])[CH3:12])[C:9]([OH:32])=[O:8])=[O:31]

Participants

5

Reactant 2

HCID 70094582HCID 70094582, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22612435HCID 22612435, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of dimethylcarbamoylmethyl(4-methoxybenzenesulfonyl)amino-3-methylbutyric acid benzyl ester (1.77 grams, 3.83 mmol) in ethanol (100 mL) was added 10% palladium on activated carbon (644 mg). The mixture was agitated under 3 atmospheres hydrogen in a Parr shaker for 1.5 hours. The catalyst was removed by filtration through nylon (pore size 0.45 μm) and the solvent was evaporated leaving dimethylcarbamoylmethyl(4-methoxybenzenesulfonyl)amino-3-methylbutyric acid as a white foam, 1.42 grams (100%).

Workup

  1. customThe catalyst was removed by filtration through nylon (pore size 0.45 μm)
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-6841f629d75c48f58f5e2a946d0dd87d
Source dataset
uspto-grants-1999_01
Patent number
US05863949

Reaction notes

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