HCID 18473639, compound → HCID 9800129, compound

HRID 343989Notes

Reaction equation

HRID 343989 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:25]=[CH:26][C:27]=2[O:28][CH3:29])[CH2:10][N:11]2[C:19]3[N:18]=[C:17]([CH:20]([CH3:22])[CH3:21])[NH:16][C:15]=3[C:14](=[O:23])[NH:13][C:12]2=S)[CH2:5][CH2:4][CH2:3][CH2:2]1>[OH-].[Na+].[Ni]>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:25]=[CH:26][C:27]=2[O:28][CH3:29])[CH2:10][N:11]2[C:19]3[N:18]=[C:17]([CH:20]([CH3:22])[CH3:21])[NH:16][C:15]=3[C:14](=[O:23])[N:13]=[CH:12]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 18473639HCID 18473639, compound

Product 1

HCID 9800129HCID 9800129, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 14798Sodium HydroxideSolvent

Procedure

4.15 g (10 mM) of 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-2-thioxanthine was dissolved in 42 ml of 1N NaOH and treated with three portions of 3 g of Raney-nickel with 0.5 hour intervals. After a further 0.5 hour, the nickel was filtered off and the solution acidified with 8 ml of 5N HCl to pH 3 and then neutralized with sodium bicarbonate solution to pH 7. The solid was collected, washed and dried: 3.62 g (94.5%) of hypoxanthine having a melting point of 243°-4° C.

Workup

  1. filtrationthe nickel was filtered off
  2. customThe solid was collected
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-49b327549f4443e7b5a2d6835ee3f067
Source dataset
uspto-grants-1999_01
Patent number
US05864037

Reaction notes

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