Ammonium Chloride → HCID 54275133, compound

HRID 344038Notes

Reaction equation

HRID 344038 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][C:7]([C:13](OC)=[O:14])=[CH:8]2.[H-].[Cl-].[NH4+]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][C:7]([CH2:13][OH:14])=[CH:8]2

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 166653HydrideHCID 14274484HCID 14274484, compound

Product 1

HCID 54275133HCID 54275133, compoundYield 6,219.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of methyl (5-methoxy-3,4-dihydro-2-naphthyl)formate (0.75 g) in toluene (10 ml) was added dropwise a solution of diisobutylalminum hydride [1.02N in toluene (6.7 ml)] at 4° C.~6° C. under nitrogen atmosphere. The reaction mixture was stirred under same conditions for 2.5 hours. The mixture was poured into a saturated ammonium chloride solution, and the organic layer was separated, washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give crude (5-methoxy-3,4-dihydro-2-naphthyl)methanol as a colorless oil 40.66 g).

Workup

  1. customthe organic layer was separated
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-59f9406726204044a972c5dd3629ff8a
Source dataset
uspto-grants-1999_01
Patent number
US05863918

Reaction notes

Loading…