反应详情

A suspension of (5-hydroxy-1,2,3,4-tetrahydro-1-naphthyl)methanol (0.20 g), ethyl bromoacetate (0.15 ml), potassium iodide (catalytic amount) and potassium carbonate (0.20 g) in acetonitrile (10 ml) was stirred under reflux for 2.5 hours. The solvent was removed and the residue was partitioned between ether and 1N hydrochloric acid. The organic layer was washed with water and brine, dried over sodium sulfate, and evaporated in vacuo. The residue was chromatographed (n-hexane-ethyl acetate) over silica gel to afford (5-ethoxycarbonylmethoxy-1,2,3,4-tetrahydro-1-naphthyl)methanol (0.29 g) as an oil.

1. temperatureunder reflux for 2.5 hours
2. customThe solvent was removed
3. customthe residue was partitioned between ether and 1N hydrochloric acid
4. washThe organic layer was washed with water and brine
5. dry with materialdried over sodium sulfate
6. customevaporated in vacuo
7. customThe residue was chromatographed (n-hexane-ethyl acetate) over silica gel