HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexyl isocyanate → 1-Cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexyl isocyanate | HCID 18502 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-(2,6-dichlorophenyl)-2-N-[4-(diethylamino)butyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328133 | — |
| Reactant | Acetonitrile methanol | HCID 21959252 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea | HCID 5328136 | 71.9% |
Reaction Steps
6-(2,6-Dichlorophenyl)-N2 -(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (1.0 g) from Example 53 in DMF (15 mL) was reacted with 60% sodium hydride suspension (0.092 g) and cyclohexyl isocyanate (0.289 g) according to the general procedure of Example 54 to give 0.927 g of the title compound, ESMS (20/80 MeOH/CH3CN+0.1% AcOH): M+ +H=558, 433.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05733913 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-a49379abcf2e4a209bfcea21a184af43 |
| Source note | uspto-grants-1998_03 |