反应详情

温度

140 °C

960 mg (2.5 mmol) of 4'-[(2-n-butyl-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid are dissolved in 25 ml of methylene chloride, treated with 2 ml of thionyl chloride and heated under reflux for one hour. The solvent is then distilled off and evaporated 2 times after adding methylene chloride. 390 mg (2.5 mmol) of benzenesulphonamide are added to the residue and the mixture is heated for one hour at 140° C. After cooling, the oil obtained is taken up in ethyl acetate/sodium chloride solution and extracted 3 times using ethyl acetate. The combined ethyl acetate phases are dried over sodium sulphate, evaporated and the crude product obtained is purified over a silica gel column using methylene chloride/ethanol as eluting agent.

1. temperatureheated
2. temperatureunder reflux for one hour
3. distillationThe solvent is then distilled off
4. customevaporated 2 times
5. additionafter adding methylene chloride
6. temperatureAfter cooling
7. customthe oil obtained
8. extractionextracted 3 times
9. dry with materialThe combined ethyl acetate phases are dried over sodium sulphate
10. customevaporated