HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (3S)-5-Oxo-1-[(1S)-1-phenylethyl]-3-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 13772856 | HCID 13772856 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3S)-5-Oxo-1-[(1S)-1-phenylethyl]-3-pyrrolidinecarboxamide | HCID 54306395 | — |
Reaction Steps
Methyl (3S)-1-((S)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylate (738 g) was dissolved in methanol (3.5 l). The solution was stirred for 8 hr under ice-cooling while blowing in ammonia gas, and concentrated under reduced pressure to give 537 g of (3S)-1-((S)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05864039 |
| Source dataset | uspto-grants-1999_01 |
| ORD ID | ord-7e028c2a0d4441d7915cc072e27e9c74 |
| Source note | uspto-grants-1999_01 |