Hydrochloric Acid → HCID 54083938, compound

Participants

Reaction Steps

Aluminum chloride (1.31 g) was added to a solution of 6-bromohexanoyl chloride (2 g) in 1,2-dichlorobenzene (20 ml) under ice-cooling and the mixture was stirred at 60°-70° C. for 1.5 hr. Ice water and conc. hydrochloric acid were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give 0.47 g of 6-bromo-1-(3,4-dichlorophenyl)-1-hexanone.

Provenance & Evidence