2-Fluoroanisole → HCID 54318304, compound

HRID 344261Notes

Reaction equation

HRID 344261 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16](Cl)=[O:17].[Cl-].[Al+3].[Cl-].[Cl-]>>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:6]1[CH:5]=[CH:4][C:3]([O:8][CH3:9])=[C:2]([F:1])[CH:7]=1)=[O:17]

Participants

4

Reactant 3

HCID 675762-FluoroanisoleHCID 898486-Bromohexanoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 54318304HCID 54318304, compoundYield 93.4%

Procedure

2-Fluoroanisole (1.18 g), 6-bromohexanoyl chloride (2.0 g) and aluminum chloride (1.31 g) were reacted and treated in the same manner as in Preparation Example 105 to give 2.65 g of 6-bromo-1-(3-fluoro-4-methoxyphenyl)-1-hexanone.

Workup

  1. additiontreated in the same manner as in Preparation Example 105

Sources & evidence

ORD record
ord-ae833a9f9084402a92b8ae5f83ab1401
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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