Hydrochloric Acid → HCID 70073828, compound

Participants

Reaction Steps

6-Bromohexanoyl chloride (2 g) and benzo[b]thiophene (1.26 g) were dissolved in methylene chloride (20 ml), and aluminum chloride (1.31 g) was added under ice-cooling, which was followed by stirring at room temperature for 1.5 hr. Ice water and conc. hydrochloric acid were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography and recrystallized from ethyl acetate-hexane to give 0.45 g of 6-bromo-1-(2-benzo[b]thienyl)-1-hexanone.

Provenance & Evidence