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HRID344281

反应详情

EQUATION

反应方程式

HRID 344281 的结构方程式

REACTANTS

反应物

2
结构：O=C1c2ccccc2C(=O)N1CCCCCCBr
HCID141120

N-(6-Bromohexyl)phthalimide

C14H16BrNO2

结构：COc1cc(N)c(Cl)cc1C(=O)NCC1CCNCC1.Cl.Cl
HCID69966330

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCCN2C(=O)c3ccccc3C2=O)CC1
HCID54520676

未命名化合物

收率 70.3%

PROCEDURE

实验过程

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (17.0 g) and N-(6-bromohexyl)phthalimide (17.4 g) were reacted and treated in the same manner as in Preparation Example 150 to give 17.0 g of 4-amino-5-chloro-N-(1-(6-(2,3-dihydro-1,3-dioxo-1 H-isoindol-2-yl)hexyl)piperidin-4-ylmethyl)-2-methoxybenzamide.

WORKUP

后处理

  1. additiontreated in the same manner as in Preparation Example 150